The world’s most comprehensive and practical reference source about drugs and medicines

Unrivalled in its field, Martindale provides practical, evidence-based, global guidance, allowing you to quickly understand the characteristics of drugs and other pharmaceutical substances and their clinical uses.

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Global source of information: International, multi-lingual coverage, including synonyms, drug and chemical identifiers, chemical formulae, structures and pharmacopeial standards

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Breadth of content: Expertly curated data on over 248,000 medicines provides an unparalleled, consolidated database of preparations

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Range of drugs: Provides concise and accurate information on herbals, diagnostic agents, radiopharmaceuticals, pharmaceutical excipients, toxins and poisons

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Reviewed and updated every 3 months by expert teams

7,500 +

drugs

54,000

references

40

regions and countries covered

6 +

languages

Publication Updates

09 Mar
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Martindale: The Complete Drug Reference March 2021 Update

This update contains 3 new monographs and 1 existing monograph has been updated. Preparations have been updated for 4 countries.

New monographs:
• Elapegademase is a recombinant form of the pegylated enzyme adenosine deaminase (pegademase). It is used in the treatment of severe combined immunodeficiency disease associated with a deficiency of adenosine deaminase.
• Lefamulin is a pleuromutilin antibacterial used for the treatment of community-acquired bacterial pneumonia.
• Vestronidase alfa is a recombinant human lysosomal beta-glucuronidase used as enzyme replacement therapy for the treatment of the non-neurological manifestations of mucopolysaccharidosis VII.

Notable revisions:
• Dexamethasone is being tried in the treatment of COVID-19 (coronavirus disease 2019) infection.

Updated names, synonyms and codes; official standards; official preparations:
• Entries for USP and USNF have been updated for USP 43-USNF 38

Proprietary Preparations and Manufacturers updated for the following countries and regions:
• Brazil
• Hong Kong
• UK†
• USA†
† Countries updated on an ongoing basis

08 Dec
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Martindale: The Complete Drug Reference December 2020 Update

This update contains 5 new monographs and 1 existing monograph has been updated. Preparations have been updated for 7 countries.

New monographs:

• Crizanlizumab is a human immunoglobulin G2 monoclonal antibody, that binds to P-selectin, used to reduce the frequency of vaso-occlusive crises in sickle-cell disease.

• Elexacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector used with ivacaftor and tezacaftor in the treatment of cystic fibrosis in patients who have at least one F508del mutation in the CFTR gene.

• Lumateperone is an atypical antipsychotic used for the treatment of schizophrenia.

• Teprotumumab is a recombinant human monoclonal antibody, directed against the insulin-like growth factor-1 receptor, used for the treatment of thyroid eye disease (Graves’ ophthalmopathy).

• Trifarotene is a retinoid analogue used topically in the treatment of acne vulgaris of the face and body.

Notable revision:

• Eltrombopag is used with standard immunosuppressive therapy for the first-line treatment of patients aged 2 years and older with severe aplastic anaemia.

Proprietary Preparations and Manufacturers updated for the following countries and regions:

• Argentina
• Australia
• Greece
• Malaysia
• Portugal
• USA†
• UK†
† Countries updated on an ongoing basis

08 Sep
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Martindale: The Complete Drug Reference September 2020 Update

This update contains 5 new monographs. Preparations have been updated for 7 countries.

New monographs:

• Cefiderocol is a siderophore cephalosporin approved for the treatment of infections due to aerobic Gram-negative organisms in adults with limited treatment options.

• Givosiran, a small interfering RNA, that is used in the treatment of acute hepatic porphyria.

• Lasmiditan is a selective serotonin agonist and can be used to treat acute migraine.

• Luspatercept is a recombinant fusion protein that acts as an erythroid maturation agent. It is used to treat transfusion-dependent anaemia associated with beta-thalassaemia or myelodysplastic syndromes.

• Voxelotor is a haemoglobin oxygen-affinity modulator in the management of sickle-cell disease.

Proprietary Preparations and Manufacturers updated for the following countries and regions:

• Hungary
• Indonesia
• New Zealand
• Russia
• Turkey
• USA†
• UK†
† Countries updated on an ongoing basis

 
09 Jun
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Martindale: The Complete Drug Reference June 2020 Update

This update contains 1 new monograph and 2 existing monographs have been updated. Preparations have been updated for 7 countries.  

New monographs: 

  • Remdesivir is a nucleotide RNA polymerase inhibitor with antiviral activity that is being tried in the treatment of severe COVID-19 (coronavirus disease 2019) infection.

Notable revisions: 

  • Chloroquine is being tried in the treatment of COVID-19 (coronavirus disease 2019) infection.
  • Hydroxychloroquine is being tried in the treatment of COVID-19 (coronavirus disease 2019) infection.

Proprietary Preparations and Manufacturers updated for the following countries and regions: 

  • Chile
  • France
  • Monaco
  • India
  • Ukraine
  • USA
  • UK

† Countries updated on an ongoing basis 

 

10 Mar
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Martindale: The Complete Drug Reference March 2020 Update

This update contains 10 new monographs and 7 existing monographs have been updated. Preparations have been updated for 2 countries.

New monographs:

  • Activin A-neutralising antibodies have been investigated for the treatment of muscle wasting disorders, and may be subject to abuse in sport.
  • 2-Androstenol is reported to be an aromatase inhibitor and may be subject to abuse in sport.
  • 3-Androstenol is reported to be an aromatase inhibitor and may be subject to abuse in sport.
  • 2-Androstenone is reported to be an aromatase inhibitor and may be subject to abuse in sport.
  • 3-Androstenone is reported to be an aromatase inhibitor and may be subject to abuse in sport.
  • 1,2-Dimethylpentylamine may be subject to abuse in sport.
  • 1,4-Dimethylpentylamine may be subject to abuse in sport.
  • Epiandrosterone is reported to be an aromatase inhibitor and may be subject to abuse in sport.
  • 1-Epiandrosterone is reported to be an aromatase inhibitor and may be subject to abuse in sport.
  • Methylclostebol is reported to be an anabolic androgenic steroid and may be subject to abuse in sport.

Notable revisions:

  • Deprodone is a corticosteroid used topically for various skin conditions.
  • Revaprazan is a proton pump inhibitor used for gastritis and peptic ulcer disease.
  • Guanidine hydrochloride is used in the treatment of Eaton-Lambert myasthenic syndrome.

Updated names, synonyms and codes; official standards; official preparations:

  • Drugs in Sport classification updated to reflect WADA Prohibited List 2020

Proprietary Preparations and Manufacturers updated for the following countries and regions:

  • USA†
  • UK†

† Countries updated on an ongoing basis

10 Dec
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Martindale: The Complete Drug Reference December 2019 Update

This update contains 11 new monographs and 13 existing monographs have been updated. Preparations have been updated for 3 countries.  

New monographs: 

  • Alpelisib: is a PI3K inhibitor used for the treatment of HR-positive, HER2-negative, PIK3CA-mutated, advanced or metastatic breast cancer. 
  • Bremelanotide: is a melanocortin receptor agonist used for the treatment of hypoactive sexual desire disorder in premenopausal women. 
  • Darolutamide: is an anti-androgen used for the treatment of non-metastatic, castration-resistant prostate cancer. 
  • Duvelisib: is a PI3K inhibitor used for the treatment of chronic lymphocytic leukaemia, small lymphocytic lymphoma, and follicular lymphoma. 
  • Erdafitinib: is a tyrosine kinase inhibitor, with activity against the fibroblast growth factor receptor (FGFR), used for the treatment of locally advanced or metastatic urothelial cancer. 
  • Fedratinib: is a Janus kinase JAK2 and FMS-like tyrosine kinase 3 (FLT3) inhibitor used for the treatment of myelofibrosis.
  • Moxetumomab pasudotox: is a CD22-directed cytotoxin, composed of a murine monoclonal antibody fragment fused with a Pseudomonal exotoxin A fragment, used for the treatment of relapsed or refractory hairy-cell leukaemia. 
  • Polatuzumab vedotin: is an antibody-drug conjugate used for the treatment of diffuse large B-cell lymphoma. 
  • Selinexor: is an orally active nuclear export inhibitor used for the treatment of multiple myeloma. 
  • Sotagliflozin: is a dual SGLT1/2 inhibitor used in the management of type 1 diabetes mellitus. 
  • Tenapanor: is a sodium/hydrogen exchanger 3 (NHE3) inhibitor used for the treatment of constipation-predominant irritable bowel syndrome. 

Notable revisions: 

  • Alemtuzumab: serious immune-mediated conditions, stroke, tears in the lining of arteries in the head and neck, and severe neutropenia, including fatalities, have been reported. 
  • Anakinra: can be used for the treatment of Still’s disease. 
  • Asparaginase: calaspargase pegol, a pegylated form of asparaginase, is used for the treatment of acute lymphoblastic leukaemia in children and young adults. 
  • Brivaracetam: can be used in children from 4 years of age for adjunctive therapy and monotherapy of partial onset seizures. 
  • Cannabidiol: can be used for the treatment of Dravet syndrome and Lennox-Gastaut syndrome in patients aged 2 years and older. 
  • Dapagliflozin: necrotising fasciitis of the perineum have been reported in patients taking sodium-glucose co-transporter 2 (SGLT2) inhibitors. 
  • Glucagon: an intranasal formulation can be used for the treatment of severe hypoglycaemia in diabetic patients aged 4 years and older. 
  • Hydrocortisone: muco-adhesive buccal tablets should not be used off-label for adrenal insufficiency due to serious risks. 
  • Lacosamide: can be used as monotherapy or adjunctive therapy in partial seizures, with or without secondary generalisation, in children from 4 years of age. 
  • Midazolam: an intranasal spray can be used for acute treatment of intermittent, stereotypical episodes of increased seizure activity that are distinct from the usual seizure pattern in patients with epilepsy aged 12 years and older. 
  • Mycophenolate: pregnancy abstract updated with advice from the MHRA about its use in female and male patients of reproductive potential. 
  • Ruxolitinib: can be used for the treatment of acute graft-versus-host disease that is steroid refractory in adults and children aged 12 years and older. 
  • Valproate: is considered highly teratogenic and restrictions have been placed on its use during pregnancy. 

Proprietary Preparations and Manufacturers updated for the following countries and regions: 

  • Switzerland 
  • USA
  • UK

† Countries updated on an ongoing basis 

 

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